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T8560 |
Angiotensin II human acetate
|
Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate |
Apoptosis
,
RAAS
|
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Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. |
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T1615 |
Irbesartan
|
SR-47436,BMS-186295 |
Apoptosis
,
RAAS
|
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Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. |
|
T27762 |
L-162,313
|
L-162313,L 162,313,L162,313 |
RAAS
|
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L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. |
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T8315 |
1-Cyclohexyl-3-dodecyl urea
|
CDU,N-Cyclohexyl-N-dodecyl urea,NCND |
Epoxide Hydrolase
|
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1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. |
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T66580 |
Azilsartan Methyl Ester
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|
RAAS
|
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Azilsartan Methyl Ester is an angiotensin II receptor antagonist. Azilsartan Methyl Ester inhibits specific binding of [125I]AII (0.2 nM) to bovine adrenal cortex with IC50 value is 0.44uM. |
|
T67848 |
Valsartan Methyl Ester
|
|
RAAS
|
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Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM. |
|
T7577 |
Angiotensin III, human, mouse
|
Angiotensin III, human, mouse(3TFA) |
RAAS
|
|
Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA))(3TFA) is an endogenous angiotensin II receptor (AT2R) agonist(IC50s of 0.648 nM). |
|
TP2158 |
TRV-120027 TFA
|
TRV-120027 TFA (1234510-46-3 free base) |
RAAS
,
Arrestin
|
|
TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling. |
|
T2400 |
Candesartan Cilexetil
|
TCV-116 |
Apoptosis
,
RAAS
|
|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with... |
|
T7339 |
Angiotensin (1-7)
|
Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO |
RAAS
,
Endogenous Metabolite
|
|
Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activiti... |
|
T6219 |
Azilsartan Medoxomil
|
TAK-491 |
RAAS
|
|
Azilsartan Medoxomil (TAK-491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. |
|
T1570 |
Telmisartan
|
BIBR 277 |
RAAS
,
Autophagy
|
|
Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist. |
|
T7797 |
Tasosartan
|
WAY-ANA 756 |
RAAS
|
|
Tasosartan (WAY-ANA 756) is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM). |
|
T5355 |
Sparsentan
|
RE-021,DARA-a |
RAAS
,
Endothelin Receptor
|
|
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively) |
|
T76169 |
Angiotensin-converting enzyme
|
|
|
|
Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, converts inactive Angiotensin I (Ang I) to its active form, Angiotensin II (Ang II), and degrades active bradykinin (BK), functioning as a potent vasoconstrictor... |
|
T70324 |
EGFR-IN-557
|
|
|
|
EGFR-IN-557 is an EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis. |
|
T69807 |
EGFR-IN-451
|
|
|
|
EGFR-IN-451 is an EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis. |
|
T26802 |
BIBS-222
|
BIBS 222 |
|
|
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. |
|
TP1218 |
Atrial natriuretic factor (1-28) (rat) TFA
|
Atrial Natriuretic Peptide (ANP) (1-28), rat TFA |
|
|
Atrial Natriuretic Peptide (ANP) (1-28),rat (TFA) is the main circulating forms of Atrial Natriuretic Peptide (ANP) in rats, which strongly inhibit the secretion of Ang II - stimulated endothelin-1. |
|
T27229 |
E-4177
|
E4177 |
|
|
E-4177 is an angiotensin type 1 receptor antagonist. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal... |
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T63820 |
DCN1-UBC12-IN-2
|
|
|
|
DCN1-UBC12-IN-2 is a potent, specific DCN1-UBC12 inhibitor with an IC50 value of 9.55 nM. DCN1-UBC12-IN-2 specifically targets DCN1-UBC12 interactions and slows Ang II-induced activation of cardiac fibroblasts. |
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T75238 |
YS-49 monohydrate
|
|
|
|
YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated... |
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T37495 |
Angiotensin (1-7) (acetate)
|
|
|
|
Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through its anti-inflammatory and anti-fibrotic activities in cardiac cells. It e... |
|
T60713 |
TK-129
|
|
|
|
TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used... |
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T37496 |
Alamandine
|
|
|
|
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). H... |
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T11808 |
L162389
|
|
RAAS
|
|
L162389 is a potent angiotensin AT1 receptor antagonist with Ki of 28 nM. |
